The pancreatic team of General Surgery department of Peking Union Medical College Hospital (PUMCH), in the past seven years, researched into the micro-environment of pancreatic cancer, and made a breakthrough in discovering a new target to boost the efficacy of chemotherapy.
The research won the third prize of the hospital's 2018 Medical Research Award. Guided by President Zhao Yupei and Director Liao Quan, surgeons including Liu looked into new targets based on micro-environment. The team, based on General Surgery, consists members from Pathology, Medical Oncology, Central Lab and others. In seven years, it achieved original research results in the examination of key immunocytes, the domestication of key immunocytes by tumor cells, the leading to drug resistance by key immunocytes and new methods to improve chemotherapy.
The research revealed that M2 macrophages, TGF-β1and GM-CSF are independent danger factors in the poor effect of Gemcitabine chemotherapy. Combined blocking of TGF-β1and GM-CSF can improve the Gemcitabine induced micro-environment and improve the drug's efficacy. Several SCI essays have been published on the findings and application filed for national invention patent.
Source:China Daily
